To date, a strategy that focuses on applying data science to advance injury and violence prevention has not been developed. In early 2019, the CDC’s Injury Center’s Office of Strategy and Innovation convened an internal working group, recognizing the potential public health benefits from implementing an injury and violence prevention data science strategy. The work group was comprised of a diverse group of leaders and subject matter experts from across the center to develop the first data science strategy for injury and violence prevention. This report reflects the results of these discussions and outlines specific goals for data science activities at the Injury Center. Progress in each of these critical areas will help solve immediate needs that exist in the field of injury and violence prevention and contribute to lessening the burden of injury and violence.